Caffeine is one of the most comprehensively studied ingredients in the food supply. The over-consumption of caffeine can cause feelings of anxiety, hyperactivity, nervousness and sleep disturbance. What are the negative impacts of caffeine?Ĭaffeine is a stimulant drug, which means it speeds up the messages traveling between the brain and the body. People with lactose intolerance or with a whey or casein sensitivity will not flow this advice general advice. As an example, the dietary guidelines tell us to consume two servings of dairy per day. The one size fits all dietary advice is often calculated as an average response of the population. What about the people in the study who had "negative" experience or no significant change at all? But, this doesn't mean the hypothesis holds for everybody. Īs with all studies, a significant proportion of participants can experience a "positive" outcome of the tested hypothesis. A better understanding of the factors influencing caffeine intake could help identify critical factors affecting the quality of life and/or susceptibility to disease. įurther research into caffeine could categorise populations by genotype and consider caffeine consumption's impact on various functions. ĭuring pregnancy, caffeine metabolism is reduced, particularly during the third trimester. Grapefruit juice decreases caffeine clearance by 23% and prolongs half-life by 31%. Īlcohol intake of 50g per day prolongs caffeine half-life by 72% and decreases caffeine clearance by 36%. The use of oral contraceptives almost doubles caffeine half-life, mainly during the second half of the menstrual cycle (the luteal phase). Several individual, non-genetic factors, can also impact the way caffeine is metabolised and utilised in the body, including liver disease, smoking, diet, pregnancy, alcohol intake, medications, and metabolism. Caffeine is then distributed throughout the body and it easily passes into the brain, breast milk and the placenta. It worth noting that the half-life of caffeine in the body can not simply be measured by how stimulated you feel.įollowing oral consumption, caffeine is absorbed into the blood and body tissues. The half-life of caffeine is not constant. Those with neither the fast or slow genes take between 4-8hr to drop caffeine levels by half. A slow caffeine metabolisers take between 8-10 hours to drop caffeine levels by half. Fast caffeine metabolisers take between 4-6 hours to lower caffeine levels by half, the half-life of caffeine. Unfortunately, about 50% of the population has a variant in the CYP1A2 gene that leads to the slow metabolism of caffeine.Ĭertain genes can dictate the metabolism of caffeine. We've been told that coffee is healthy for us, but what if it not?Ĭaffeine is metabolised by an enzyme in the liver that is encoded by the CYP1A2 gene. However, recent research suggests that the effects of coffee on health aren’t the same for everyone, and may depend on genetics and other factors.Ĭaffeine is the most widely consumed psychoactive substance globally, 90% of adults consume caffeine regularly (coffee, tea, cola, energy drinks, pre-workout supplements and more). Numerous studies have linked caffeine with positive health effects like reduced risk of obesity, diabetes, and heart disease. I was a little curious to find out what this means and what positive or negative effects caffeine can have on our health and performance? I recently did an ancestry gene test and discovered that I'm in the 50% of the population who are slow caffeine metabolisers (CYP1A2 AC and CC genotype).
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